Annual Gene Therapy Symposium for
Heart, Lung, and Blood Diseases
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2002

UC Davis

 


1st Annual Gene Therapy Symposium for Heart, Lung, and Blood Diseases
Focus Topic: Stem Cells
November 14-15, 2002 - Davis, California

Program

 

Thursday, November 14, 2002

Keynote Speaker
• Donald B. Kohn, M.D. (Childrens Hospital Los Angeles)
"Gene Therapy Using Hematopoietic Stem Cells"

Presentation Topic: Vectors
• John J. Rossi, Ph.D. (City of Hope National Medical Center)
“Combinatorial Ribozyme, Decoy and Sirna Therapies for HIV-1”
• Bruce A. Bunnell, Ph.D. (Tulane University Health Sciences Center)
"Analysis of Gene Transfer Efficiency and Gene Expression with Equine Infectious Anemia Virus (EIAV) Derived Lentivirus Vectors"
• James G. Hecker, M.D., Ph.D. (University of Pennsylvania)
"Non-Viral Gene Delivery for Selected Clinical Applications"


Student/Fellow Presentations
• Kolbot By, B.S. (UC Davis)
"Synthesis of PH-Vulnerable Amphiphiles for Gene Therapy"
• Chang I. Lee, B.S. (UC Davis)
"Transduction of Fetal Monkey Mesenchymal Stem Cells with Lentiviral Vectors"
• Mingjie Li, Ph.D. (City of Hope National Medical Center)
"Inhibition of HIV-1 Infection by Lentiviral Vector Carrying ANTI-CCR-5 Ribozyme and Tar Decoy"
• Carolyn Lutzko, Ph.D. (Childrens Hospital Los Angeles)
"Development of Lentiviral Vectors with Position Independent Transgene Expression in Human and Murine B-Lymphoid Cells"
• Natalya Perelman, M.S. (Childrens Hospital Los Angeles)
"Enthyroid-Specific Self-Inactivating Lentiviral Vectors Suffer from Position Effects"
• Patrick L. Sinn, Ph.D. (University of Iowa)
"Pseudotyping Feline Immunodeficiency Virus (FIV)-Based Vectors to Target the Apical Surface of Differentiated Human Airway Epithelia"

Presentation Topic: Heart, Lung, and Blood
• Judith A. St. George, Ph.D. (Genzyme Corporation)
"Results of Phase I Gene Therapy Clinical Trials for Cystic Fibrosis: Answers but More Questions"
• Paul B. McCray, M.D. (University of Iowa)
"Pseudotyping Lentiviral Vectors for Therapeutic Targets"
• Karin M. Gaensler, M.D. (UC San Francisco)
"Viral-Mediated In Utero Gene Transfer to the Developing Mouse Fetus"
• Alice F. Tarantal, Ph.D. (UC Davis)
"Fetal Gene Therapy for Congenital Heart, Lung, and Blood Diseases - A Future Reality?"

Practical Strategies: Stem Cells
• Gay M. Crooks, M.D. (Childrens Hospital Los Angeles)
"Isolation and Assay of Hematopoietic Stem Cells"

Dinner Speaker
• Inder M. Verma, Ph.D. (The Salk Institute)
"Gene Therapy: Medicine of the 21st Century"  

Friday, November 15, 2002

Workshop: Human Embryonic Stem Cells
• Meri T. Firpo, Ph.D. (UC San Francisco)
"Derivation and Differentiation of Human Embryonic Stem Cells"

Session I
• Connie J. Eaves, Ph.D. (The Terry Fox Laboratory)
"Hematopoietic Stem Cells – Lessons for Gene Therapy"
• Robert G. Andrews, M.D. (Fred Hutchinson Cancer Research Center)
"Gene Transfer into Hematopoietic Stem Cells of Non-Human Primates"
• Morton J. Cowan, M.D. (UC San Francisco)
"In Utero Hematopoietic Stem Cell Transplantation: The Issue of 'Space' "
• Stanton L. Gerson, M.D. (Case Western Reserve University)
"Stem Cell Selection In Vivo Using the MGMT Drug Resistance Gene "

Student/Fellow Presentations
• Sawati Bhattacharyya, Ph.D. (UC San Francisco)
"Role of Co-Stimulatory Molecules in Alloengraftment Post In Utero Transplantation"
• Michael E. Bowdish, M.D. (University of Southern California)
"Use of an Aortic Pouch Model to Capture Blood-Circulating Mesenchymal Stem Cells"
• Jason E. Ekert, Ph.D. (UC Davis)
"In Vitro Characterization of Rhesus Monkey Bone Marrow-Derived Mesenchymal Stem Cells from Fetal and Juvenile Donors"
• Li Liu, Ph.D. (UC Davis)
"Liposome-Mediated Extracellular Superoxide Dismutase Gene Delivery Protects Against Reactive Oxygen Species-Associated Hepatocellular Injury In Vitro and In Vivo"
• Ryan Rodriguez, B.S. (UC San Francisco)
"Genetic Modification of Embryonic Stem Cells"
• Steven Zielske, M.A. (Case Western Reserve University)
"Human NOD/SCID Repopulating Cells Lentivirus-Transduced with P140K MGMT have a Selective Advantage and are Enriched In Vivo after BG/BCNU Treatment without Pre-Transplant Irradiation Conditioning"



Session II
• Jan A. Nolta, Ph.D. (Washington University)
"Human Mesenchymal Stem Cell Trafficking Studies are Facilitated by Novel Murine Xenotransplantation Models"
• Victor K. Han, M.D., F.R.C.P. (Child Health Research Center)
"Human Stem Cells from Cord Blood and Placenta: Potential Sources of Regenerative and Transplant Therapy for Newborns and Children"
• David R. Warburton, D.S.C., M.D., F.R.C.P. (Childrens Hospital Los Angeles)
"Stem Cells in Lung Morphogenesis, Repair, and Regeneration"

Concluding Comments
• Alice F. Tarantal, Ph.D. (UC Davis)

 

 
  Supported by the National Heart, Lung, and Blood Institute, National Institutes of Health, with additional support provided by the California National Primate Research Center and StemCell Technologies.